Urolithin A is a bacterial metabolite that enhances mitophagy, which declines as we age and allows dysfunctional mitochondria to accumulate.
Human gut bacteria create urolithin A (UA) when exposed to dietary polyphenolic substances such as ellagic acid (EA) and ellagitannins (ET), such as punicalagin. These polyphenolic precursors can be found in a variety of fruits and nuts (including pomegranate and some berries) (walnuts and pecans). ET is converted to EA in the upper gastrointestinal tract and then metabolized by gut bacteria in the large intestine into urolithins, the most frequent of which is UA. Variations in the microbiota responsible for ET metabolism cause substantial variances in urolithin production capability among individuals. Urolithins, such as UA, are absorbed and converted in the liver, then eliminated in the urine and feces. UA and its two main detectable metabolites, UA glucuronide, and UA sulfate, have been found to be the most prevalent urolithin forms in circulation in several investigations.
Urolithin A Boosts Mitophagy & Metabolism
Urolithin A, the metabolites of the dietary compound urolithin, is a newly identified compound that promotes healthy aging.
Urolithin A is produced naturally in the body when we eat certain food sources such as pomegranates and blueberries. The compound is known to have anti-aging properties.
A new study conducted by researchers at the University of Washington School of Medicine provides some insight into how urolithin A works. Mitochondria are considered the powerhouses of the cell as they help generate energy from food that the cell can use. Aging results in a decline in mitochondrial function. Urolithin A stimulates mitophagy, or what lead author David Marcinek called “mitochondrial quality control.”
Marcinek, a professor of radiology at the University of Washington School of Medicine, explained: Mitochondria are like batteries that power the cells in your body, but over time they break down. Mitophagy is a process that recognizes this failure and proactively tears down.
Marcinek noted that even though they did not observe an effect of the supplement in whole body function, the results did demonstrate that taking the supplement for a short duration actually improved muscle endurance.
Additionally, the supplement was found associated with a significant reduction in several acylcarnitines and ceramides implicated for their roles in metabolic disorders involving mitochondria. These changes indicate that the treatment affects improved their general metabolism, Marcinek said.
Urolithin A supplements may benefit people who cannot get the exercise they want due to poor muscle health or disease
Is Urolithin A Safe?
Urolithin A is a newly discovered health supplement with incredible potential. Urolithin A is a natural metabolite formed in the body during the metabolism of dietary ellagitannins, found in many fruits, vegetables and wine. Urolithin A has been shown to be one of the most potent and safe regulators of mammalian lifespan and healthspan.
The inability of most people to produce Urolithin A has given rise to the first Urolithin A supplementation options. Notably, using Urolithin A as a dietary supplement has achieved GRAS status from the US FDA (2018), meaning it is ‘Generally Recognised as Safe’ for human consumption in the proscribed range of 250 mg to 1000mg per dose.
5 Best Recommended Urolithin A Supplement
Raising Urolithin A has been to have numerous benefits. Now, there’s an easy way to do it. Urolithin A Supplement features clinically proven ingredients that help raise your urolithin A levels by supporting autophagy and preventing its breakdown. With this supplement, you’ll notice increased focus, enhanced metabolism, reduced inflammation and much more!
Urolithin A is the process by which damaged and dysfunctional cells are cleared out of our body’s systems to make way for healthier ones! The researchers reported that urolithin A increased mitophagy and could be useful in preventing obesity and other metabolic diseases.
Herewith top 5 reviews to help you pick up the best one for you…
1. Zenwise Digestive Enzymes Plus Prebiotics & Probiotics Supplement
Zenwise Digestive Enzymes Plus Prebiotics & Probiotics Supplement, 180 Servings, Vegan Formula for Better Digestion & Lactose Absorption with Amylase & Bromelain, 2 Month Supply is a high quality and well-designed product. It is made of the best ingredients that are safe and effective to use. Another important aspect of this product is its fast and efficient delivery method so you are going to receive a top quality product delivered in no time at all.
At Zenwise Health, they make a range of clinically-proven products that help you maximize your health. They combine the traditions of holistic “Zen” wisdom, and the “Wise” innovations and evolutions of human wellness to create carefully crafted, plant-powered products designed to help people live better.
Digestive Enzymes with Probiotics
tablets with plant-based ingredients that are taken before meals and are designed to provide men and women with relief from occasional bloating, gas, and discomfort. Certified Vegetarian by the AVA.
Complete Gut Wellness
Restores the digestive enzymes that may be lost with increasing age. This advanced enzyme, prebiotic, and probiotic non-GMO mix is designed to help with the digestion of meals that are difficult to digest. In order to maintain regularity, digestive and immunological health. Concerns Regarding One’s Stomach Sensitivity.
De111 Probiotic Has Been Clinically Proven To Be Alive And Well
Guaranteed to arrive alive and working in the small intestine within hours, where 90 percent of nutrient absorption occurs and 70% of the immune system resides.
Wakame, Bladderwrack, Fennel, Ginger, Green Papaya, Inulin, Apple Pectin, and Turmeric are all digestive aids that soothe the stomach and promote gut health.
180 Serving Supply
1 (180 count) Zenwise Digestive Enzymes + with Pre & Probiotics is included. To experience digestive delight, take 1 capsule before each meal. No refrigeration is required.
Advanced Enzyme & Prebiotic System (Inulin, Glucoamylase, Amylase, Bromelain, Cellulase, Invertase, Lactase, Bacterial Protease, Papain, Lipase, Maltase [Aspergillus niger]), Papaya Fruit Powder, Apple Pectin, Ginger Root Powder, Sea Vegetable Complex (Nori, Wakame, Bladderwrack Extract), Fennel Seed Powder, Turmeric Root Powder, Peppermint Leaf Extract, Probiotic Blend (Bacillus subtilis DE111, Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium animalis lactis, Bifidobacterium bifidum, Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus plantarum, Lactobacillus salivarius, Bifidobacterium breve), Microcrystalline Cellulose, Capsule (Hypromellose, Water), Medium Chain Triglycerides, Magnesium Stearate, Silica. Contains Sulfites.
2. Qunol Ultra CoQ10 100mg
Qunol Ultra CoQ10 is a natural supplement featuring Ubiquinol, the active form of CoQ10. Qunol Ultra 100mg CoQ10 supports heart health, energy production, and cardiovascular function. This formula is enhanced with three valuable antioxidants – vitamin C, grape seed extract, and selenium. Qunol Ultra 100mg CoQ10 helps convert food into cellular energy throughout the day to maintain optimal health and wellness. Directions – adults take one (1) softgel per day with food, or as recommended by your healthcare professional. Keep bottle tightly closed in a cool and dry place (59 – 86 degree fahrenheit / 15 – 30 degree celsius ) and DO NOT REFRIGERATE.
3x Better Absorption
Clinical investigations have shown that Qunol absorbs CoQ10 better than any other supplement. Qunol Ultra absorbs three times better than ordinary  CoQ10.
Qunol 100mg CoQ10 has better absorption compared to conventional  CoQ10. CoQ10 softgel capsules can help you achieve ideal levels of Coenzyme Q10 more quickly, allowing you to enjoy the potential advantages more quickly.
100% Water And Fat-soluble
Qunol CoQ10’s patented formulation is 100 percent water and fat-soluble, unlike regular  CoQ10, which does not dissolve in water and dissolves very poorly in fat.
Beneficial To Statin Drug Users
Statin drugs have been known to diminish CoQ10 levels, so taking a CoQ10 supplement along with your statin medicine will help you replace what you’ve lost.
Essential For Energy Production
CoQ10 is essential for the production of energy in the body. Taking a CoQ10 supplement boosts natural CoQ10 levels, which can be depleted by aging and cholesterol-lowering statin medications.
Gelatin, polysorbate 80, medium-chain triglycerides, glycerin, hydroxylated lecithin, sorbitol, filtered water, annatto suspension in sunflower oil are among the other ingredients.
Contains soy and is free of the following ingredients: milk and milk by-products, egg and egg by-products, fish, shellfish, tree nuts, peanuts and peanut oil, wheat, gluten, starch, and yeast.
Free of gluten.
3. AZO Cranberry Urinary Tract Health Dietary Supplement
Cranberry juice is known for its ability to help maintain a healthy urinary tract and prevent urinary tract infections (UTIs). Sometimes, though, it can be difficult to drink enough cranberry juice. Now there’s an easier way to get the benefits of cranberry juice in just 1 serving of AZO Cranberry softgels.
These convenient, easy-to-swallow softgels are specifically formulated to help maintain a healthy urinary tract. AZO Cranberry is made with clinically proven Pacran, a super-concentrated whole fruit cranberry powder that helps flush to maintain urinary tract cleanliness.
Take 1 softgel daily as part of your routine to maintain a healthy urinary tract.
AZO Cranberry Urinary Supplement
Taking these softgels can help maintain a healthy urinary tract for both men and women. This product is formulated to help support the body’s natural defense system against a variety of urinary tract infections (UTIs). It may also be helpful in preventing UTIs by reducing inflammation and improving the flow of urine out of the bladder.
Ingredients From Natural Sources
These cranberry softgels are made with Pacran, a super-concentrated whole fruit cranberry blend which helps flush the urinary tract.
The softgels are formulated with a unique blend of cranberry extracts and vitamin C to help maintain a healthy urinary tract and support kidneys.
Gluten-free And Sugar-free
AZO Cranberry Softgels are a convenient way to get your daily dose of cranberry. Each serving is equal to the benefits of one glass of cranberry juice; many cranberry juice cocktails have over 42 grams of sugar and 165 calories per 12 ounce serving while AZO cranberry soft gels are sugar and gluten-free. Not a reduced calorie food.
Each bottle contains 60 tablets, which is a 30-day supply.
How To Take
Take two softgels daily with water; 100 softgels per bottle (50 day supply). For best results take one softgel in the morning and one softgel in the evening.
Softgels Are Convenient And Easy To Swallow
The active ingredient in AZO Cranberry Softgels is 100% pure cranberry juice powder. It contains no added sugar or calories.
Cranberries are well known for their ability to support urinary tract health, but drinking cranberry juice can be an inconvenient way to get the benefits of this fruit. The active ingredient in AZO Cranberry Softgels is 100% pure cranberry juice powder, which provides you with the same benefits as whole cranberries without all the extra sugar and calories found in juice drinks. These softgels are a convenient way to maintain your healthy urinary tract without extra sugar or calories found in cranberry juice.
Soybean oil, rice bran oil, gelatin, glycerin, soy lecithin, yellow beeswax, water, and colors (carob, carmine, and annatto). Contains: Soy.
4. Garden Of Life Dr. Formulated Probiotics For Women
Dr. Formulated Probiotics Once Daily Women’s is a unique “just one capsule a day” shelf stable probiotic. Once Daily Women’s is a specifically designed vegetarian supplement with a high probiotic count to support a healthy microbiome and women’s specific health needs. Dr. Perlmutter created this unique formula with a high count of beneficial probiotics made from diverse strains, including Lactobacilli and Bifidobacteria, that are resistant to stomach acid and bile, exclusively for women’s digestion, immune system health. David Perlmutter, M.D., is an expert in the human microbiome, a board-certified neurologist, Fellow of the American College of Nutrition, America’s brain-health expert and #1 New York Times best-selling author.
Once Daily Women’s is a specifically designed vegetarian supplement with a high probiotic count to support a healthy microbiome and women’s specific health needs. This shelf-stable capsule features an advanced formula that includes:
Lactobacillus acidophilus DDS-1 (Lactobacillus casei LBC80R) – An acidophilus strain isolated from human breast milk that has been shown to be highly effective against pathogenic.
Support For Digestion
This once daily probiotic supplement contains Lactobaccilus acidophilus and Bifidobacteria for digestive health and constipation relief.
Probiotics are a type of “good” bacteria that help maintain a healthy digestive system. They can be found in yogurt, but some people find that they’re not getting enough probiotics through their diet. If you’re looking for an easy way to take care of your gut, this probiotic supplement may be just what you need!
Probiotics For Women
A specially formulated probiotic for women’s specific health needs contains Lactobacillus reuteri (L. reuteri) and Lactobacillus fermentum (L. fermentum). These strains have been shown to help maintain normal vaginal flora and support healthy vaginal pH levels.
Our bodies are constantly under attack from foreign invaders like bacteria and viruses. But our immune system is a powerful force that defends us against such invaders.
This dietary supplement has 50 billion CFU and 16 probiotics for immune system health. This probiotic supplement is designed to support digestive health with 50 billion live cultures of bacteria per serving. Each capsule contains a large number of probiotic strains, including lactobacillus rhamnosus, lactobacillus acidophilus, and other microorganisms. The product also contains prebiotics to help promote healthy bacterial growth.
Each capsule provides 5 billion CFU (colony-forming units) of lactobacillus rhamnosus GG (also known as Lactobacillus GG), one of the most researched probiotics in the world. Lactobacillus rhamnosus GG is often used in combination with other strains because it is believed to have a wide range of health benefits including boosting immune function and supporting healthy digestion.
Probiotics On The Shelf
This 50 billion probiotics supplement comes in 30 one daily capsules; no refrigeration required. This is the highest potency probiotic available on the market – 50 billion CFUs per capsule! The number of CFUs is what counts when it comes to probiotics and this supplement has a very high dosage.
Gluten Free Probiotic
Digestive supplement is Non-GMO Project Verified, NSF Certified Gluten-Free, dairy-free, soy-free and vegetarian. This supplement is made with a proprietary blend of plant enzymes and prebiotics to support digestion and nutrient absorption.
It’s time to get back on track with your gut health. This probiotic formula has been specifically formulated for people with digestive issues, bloating or gas.
omen’s Daily Probiotic Blend: Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus casei, Lactobacillus paracasei, Lactobacillus bulgaricus, Lactobacillus brevis, Lactobacillus reuteri, Lactobacillus salivarius, Lactobacillus fermentum, Lactobacillus gasseri, Lactobacillus rhamnosus, Bifidobacterium lactis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium infantis, Bifidobacterium longum. Organic Prebiotic Fiber Blend: Organic Potato [Resistant Starch] (tuber), Organic Acacia Fiber (A. senegal). Other Ingredients: Non-GMO Vegetable Cellulose (capsule). Contains no carriers, fillers, artificial colors, flavors, sweeteners or preservatives.
5. Dr. Emil Nutrition 200 MG 5-HTP Plus Formula For Mood, Stress, And Sleep Support
5-HTP (5-Hydroxytryptophan) is a naturally occurring amino acid that the body uses to produce serotonin, a neurotransmitter that helps regulate mood and sleep. Synergistic 5-HTP Formula – 5-HTP is further enhanced with SAMe and L-Tryptophan, both of which have been indicated to support 5-HTP conversion. In addition, there is growing scientific evidence that both ingredients may also help the conversion of 5-HTP.
Cofactor B6 for optimal results – included a robust dosage of Vitamin B6, a vital prerequisite the body needs to convert 5-HTP. Without an optimal level of B6, the body is challenged to fully convert 5-HTP. Mood & sleep support – 5-HTP augmented blend is specifically designed for maximum benefit, which has been shown to reduce stress.
Emil’s signature blend is designed for those looking for maximum benefit in mood & sleep support. It contains a synergistic combination of ingredients that support optimal 5-HTP conversion. The formula contains cofactors such as SAMe and L-Tryptophan along with Vitamin B6 — all crucial components for effective conversion.
Supports Mood And Sleep
The supplement contains 200mg of pure 5-HTP, 20mg of SAMe and 20mg of L Tryptophan. These nutrients are included to optimize 5-HTP conversion, support stress levels in the body and help you have a better night’s rest.
The supplement also contains vitamin B6 which is required for the conversion of tryptophan into serotonin. These nutrients work together to provide you with a natural way to boost your mood and improve your sleep quality.
Contains Vitamin B6 For Improved 5-htp Conversion
Vitamin B6 has been shown to aid 5-HTP conversion. Studies show that even a slight B6 deficiency can greatly inhibit the efficacy of 5-HTP.
Vitamin B6 is essential for the metabolism of amino acids, especially tryptophan (the precursor of 5-HTP). A study published in The American Journal of Clinical Nutrition found that people who took vitamin B6 supplements for two weeks had higher levels of 5-HTP than those who did not take the supplement, and their tryptophan levels were significantly higher than those of people given a placebo.
Promotes Calm And Relaxation
Dr. Emil’s 200 MG 5-HTP Plus formula is a natural way to promote a calm and relaxed mood by supporting 5-HTP conversion in the body.
5-HTP is a dietary supplement that has been shown to help promote healthy sleep by reducing anxiety and helping you relax. This product contains 200 mg of 5-HTP per tablet, as well as other ingredients that support its effectiveness.
Dr. Emil Hodzovic has painstakingly formulated this 200 MG 5-HTP Plus supplement with the highest quality ingredients that are gluten-free, non-GMO, and manufactured in a cGMP facility to ensure that each product is 100% free of hype, and hormones. 5-HTP is a precursor to serotonin, which helps support mood balance. The serotonin produced by this amino acid plays an important role in sleep quality and appetite regulation. 5-HTP also supports digestive function and encourages healthy cell growth.
This product contains no added artificial sweeteners, flavors or colors and no preservatives.
Contributing To A Healthier World
Thanks to the customers, and through the partnership with Vitamin Angels, Dr. Emil Nutrition is helping create a healthier world for mothers and children everywhere.
What Should You Consider Purchasing Urolithin A Supplement?
Urolithin A is an extremely powerful and potent anti-oxidant. It is believed to play a big role in protecting the body from free radicals and preventing premature aging.
Urolithin A is naturally found in pomegranates, walnuts, grapes and other foods that are rich in ellagic acid. It has been shown that this compound can increase the production of sirtuin enzymes which help prevent cellular damage caused by free radicals.
Urolithin A supplements are available in several different forms including capsules, bulk powder and liquid extract. They can be purchased as a standalone supplement or as part of an overall anti-aging supplement which contains other ingredients such as pomegranate extract and resveratrol.
Choose A Brand That is Appropriate For You
The first thing you should do is to choose a brand that is appropriates for you. There are so many options available in the market, but it is important to choose one that can meet your needs and budget. The most important thing is to find a product that will work for your situation.
Customer reviews provide an outline of a product’s strengths and downsides. They add a personal touch by showing how others feel about a product. Many consumers only rate a product if they had a good or bad experience with it. Some shoppers publish reviews more than others. Some products get more reviews than others. Customer reviews are a good indicator of product satisfaction.
Urolithin A is a naturally occurring compound that is found in many foods, such as pomegranates and blueberries. It has been studied for its benefits to the cardiovascular system, but it also has potential use in improving memory, mental health, and even cancer treatment.
It is important to buy urolithin A supplements that have been tested and verified by third-party labs. The amount of urolithin A in each capsule should be listed on the label as well as on their website if they sell online (this way you can check for yourself). Higher dosages are better because they will give you more benefits and results than lower ones. However, make sure not to go overboard because too much might cause side effects such as liver damage or stomach pain!
Quality Of Ingredients
The first thing you should look at when buying a Urolithin A supplement is the quality of ingredients. When choosing this type of product, it is important to look at the exact amount of each ingredient included in each serving size. Make sure that there are no fillers or other additives added into the formula as they can cause unwanted side effects in some people.
Consider your budget
Urolithin A supplements are available in different forms and flavors. The cost of Urolithin A supplements varies according to the brand, quality, quantity and other factors. You can find affordable products as well as expensive ones on the market today.
How To Choose The Best Urolithin A Supplement?
Urolithin A is a powerful antioxidant that is produced by the body when we eat berries and pomegranates. It has been shown to support healthy aging, reduce inflammation and improve cardiovascular health.
The benefits of Urolithin A are numerous, but it can be difficult to find a high-quality supplement that contains this unique compound. The best way to ensure you’re getting the highest quality Urolithin A supplement is to look for a product that is third-party tested for purity and potency.
How Does Urolithin A Work?
Urolithin A is a precursor to Resveratrol, which has been shown to be beneficial for health in numerous studies. The exact mechanism of action for Urolithin A is not completely understood, but it may have anti-inflammatory and anti-oxidant properties. It may also be responsible for promoting autophagy, the process by which cells destroy old proteins and damaged organelles (small subunits within cells).
Where Does Urolithin A Come From?
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins (ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate, berries, and nuts.
Taking a pure urolithin A supplement can increase plasma levels of urolithin A better. Urolithin A is a naturally occurring compound that is found in many foods, such as pomegranates and blueberries. It has been studied for its benefits to the cardiovascular system, but it also has potential use in increased mitophagy, producing serotonin, maintaining a healthy urinary, and mental health, and even cancer treatment.
Urolithin A helps to protect the heart and brain from damage caused by oxidative stress, reduce blood pressure and lower cholesterol levels. It also has been shown to improve insulin sensitivity and promote weight loss.