Best Lion’s Mane Supplement

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Lion’s Mane mushroom, or Hericium Erinaceus, has been consumed for generations by practitioners of traditional Chinese medicine. It shares many similar traits with other medicinal mushrooms. The mushroom is unique because of its water-soluble beta-glucan content. These components have been scientifically proven at improving brain health and slowing the effects of aging. According to the National Center for Complementary and Integrative Health, Lion’s mane is “one of the best studied medicinal mushrooms for its beneficial effects on neurological function.

Why Should You Take a Lion’s Mane Supplement?

It has been demonstrated that lion’s mane mushrooms can increase memory, and mental clarity, and even fend off Alzheimer’s disease.

Our brains’ capacity to generate new cells declines with age. However, research indicates that eating Lion’s Mane mushrooms can encourage neuron growth and development. Because of the encouragement of new cell growth, Lion’s Mane can also act as an Alzheimer’s disease preventative.

For instance, in one study, mice’s memory loss symptoms were reduced when they ate Lion’s Mane mushrooms. Additionally, it appeared to shield mouse neurons against amyloid-beta plaques, which have been demonstrated to accumulate in the brain as Alzheimer’s disease worsens.

Consuming Lion’s Mane also lessens chronic inflammation, which is regarded to be the root of many modern diseases, thanks to its antioxidants (this includes autoimmune disorders, heart issues, and even cancer.) According to one study, the lion’s mane helps to prevent stomach ulcers by reducing inflammation.

We anticipate further human study, though, as the fungus has primarily been studied using animal models.

That being said, it’s a secure, affordable supplement. Even some entertaining forms, like coffee, are available. Therefore, let’s discuss the top lion’s mane supplements.

Best Lion’s Mane Supplement Reviews

1. Host Defense, Lion’s Mane Capsules

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Host Defense, Lion's Mane Capsules, Promotes Mental Clarity, Focus and Memory, Mushroom Supplement, Unflavored, 120
  • SAFE, SMART MUSHROOMS: Sustainably cultivated, certified organic and U.S. grown mushrooms from the forest, to our farm, to you
  • SUPPORTS COGNITIVE FUNCTION: Provides cerebral and nervous system support; Optimizes immune system health; Numerous studies have identified a Nerve Growth Factor in Lion's Mane
  • CONVENIENT, ONE-A-DAY: Simple and convenient, our vegetarian capsules are an excellent daily source of mushroom mycelium
  • GIVE YOUR BRAIN A BOOST: Clear the mental fog and give your memory and immune health a boost with Lion's Mane mushroom mycelium
  • TAKE 2 CAPSULES DAILY: Can be taken with food or without, and even on an empty stomach

Product Packaging: 

Standard Packaging

Dosage FormCapsule
Recommended Uses For ProductImmune Support, Brain Health
BrandHost Defense
Diet TypeVegetarian, Gluten Free
Age Range (Description)Adult

Harness the cognitive power of Lion’s Mane mushrooms. Our formula delivers organic mushroom mycelium to help improve mental clarity, memory and your ability to focus. Grown in the USA, Host Defense is the smartest way to tap into the brain-boosting benefits of Lion’s Mane.

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

2. Lions Mane Powder Extract Mental Clarity Capsules

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Lions Mane Powder Extract Mental Clarity Capsules - Brain & Focus Supplement - Improve Immune Support Supplement - Gluten Free
  • Reminder: A very small percentage of people may experience adverse effects when consuming mushrooms, including upset stomach, skin, and head discomfort. This may be mushroom-specific or dose-dependent. It is advised to stop consuming the product if you do not feel well. If you wish to try the product again, start with a smaller dose or consult with your health practitioner.
  • Lion's Mane Mushroom Supplement for Better Cognitive Health: Made from real lions mane mushroom extract, we use hot water extraction to obtain beneficial beta-glucans, hericenones, and thousands of other nutrients to provide unparalleled brain function with every capsule. Unlike other memory and focus supplements, we do not add mycelium, starch, grains, or fillers into our products — you only get 100% real mushrooms in every bottle.
  • Ultimate Memory Supplement for Brain: The mushrooms used to make this dietary supplement are hand-picked and analyzed by experts who have over 4 decades of mushroom growing experience to ensure we provide you with the best extract possible. Unlike other brain supplements for memory and focus, The Real Mushrooms Lion's Mane supplements have measured levels of beta-glucans (most important compound found in mushrooms) verified by 3rd party laboratories.
  • Potent Lions Mane Extract Supplement Good for 150 Days: By choosing Real Mushrooms, you get great value for your money as 1 bottle is already good for 5 months. Featuring 1000 mg of extract in each serving, our lion’s mane contains >30% beta-glucans and undergoes rigorous quality control testing to make them gluten-free, non-GMO, vegan, dairy-free & nut-free.
  • Cognition & Focus Pills Plus More Benefits: This lion's mane supplement is a natural immune support that provides overall health, wellness & superior focus factor. Besides being memory pills & mental focus supplements, it also helps improve the brain’s regenerative function while supporting mental clarity, better sleep, improved energy level, mood, and heart health — perfect for busy & active individuals with demanding lifestyles.
Special IngredientsVegan, Gluten Free, Organic, Non GMO, Nut Free, Dairy Free, Paleo, Keto, Whole 30
Dosage Form500mg capsule of lion’s mane mushroom extract powder. No added mycelium, grains or fillers.
Recommended Uses For ProductBrain Health, Cognition, Mental Clarity, Focus
BrandReal Mushrooms
Diet TypeVegetarian

The Real Mushrooms Lion’s Mane Mushroom Capsule Supplements is made using pure, potent & carefully extracted mushroom extracts.

Unlike other mushroom supplements in the market, the Real Mushrooms Lion’s Mane Mushroom Capsule Supplements is made using the mushroom’s fruiting bodies. Together with our meticulous hot water extraction process, we’re able to give you a potent & pure mushroom supplement with the highest level of bioavailable nutrients in every serving.

The Real Mushrooms Lion’s Mane Mushroom Capsule Supplements is formulated to provide you with superior cognitive support day in and day out.

Contains 100mg of mushroom extracts

A carefully hand−picked formula featuring superfood mushrooms popularly used for their immune−boosting properties.

Mushrooms have a tough cell wall made up of chitin which humans have a hard time digesting. This limits us from accessing the important compounds found in mushrooms.

Extraction is required in order to break down the cell wall and make the beneficial compounds bioavailable to us.

High-levels of beta-glucans at >20% verified by 3rd-party laboratories

Beta−glucans support our immune defenses, activate white blood cells and corrects oxidative damage.

Beta−glucans are the main active beneficial compounds in mushrooms yet very few companies list these on their products, much less measure them.

With Real Mushrooms, all our products have measured levels of beta−glucans scientifically verified to give you a high−quality and effective supplement.

No grains, mycelium or fillers for a trusted formulation

Supplied to and recommended by over 1,000 traditional Chinese health and naturopath practitioners in Canada and the USA.

Fact is, many mushroom products do not actually contain mushrooms.Most are made from the mushroom’s root system called mycelium which is mycelium is grown on grains like rice, oats, and sorghum.

MADE USING ORGANIC & NON-GMO INGREDIENTS

The Real Mushrooms Lion’s Mane Mushroom Capsule Supplements is made using non-GMO & organic ingredients.

VEGAN & GLUTEN-FREE FORMULATION FOR ALL TYPES OF DIETARY RESTRICTIONS

All of our pure mushroom extract products undergo rigorous quality control testing to ensure they are vegan, gluten-free, dairy-free & nut-free to suit all dietary restrictions.

PURE MUSHROOM EXTRACTS IN EVERY SERVING

Each serving is packed with 100% pure mushroom extract. We use our mushroom growing expertise to provide you with potent and effective supplements to boost your health & performance.

3. Organic Lions Mane Mushroom Powder Supplement

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Organic Lions Mane Mushroom Powder Supplement - Improve Cognitive and Immune Support - Gluten Free Powder Extract
  • Reminder: A very small percentage of people may experience adverse effects when consuming mushrooms, including upset stomach, skin, and head discomfort. This may be mushroom-specific or dose-dependent. It is advised to stop consuming the product if you do not feel well. If you wish to try the product again, start with a smaller dose or consult with your health practitioner.
  • Cognition & Focus Extract Plus More Benefits: This lion's mane supplement is a natural immune support that provides overall health, wellness & superior focus factor. Besides being memory extracts & mental focus supplements, it also helps improve the brain’s regenerative function while supporting mental clarity, better sleep, improved energy level, mood, and heart health — perfect for busy & active individuals with demanding lifestyles.
  • Lion's Mane Mushroom Supplement for Better Cognitive Health: Made from real lions mane mushroom extract, we use hot water extraction to obtain beneficial beta-glucans, hericenones, and thousands of other nutrients to provide unparalleled brain function with every extract. Unlike other memory and focus supplements, we do not add mycelium, starch, grains, or fillers into our products — you only get 100% real mushrooms in every pouch.
  • Ultimate Memory Supplement for Brain: The mushrooms used to make this dietary supplement are hand-picked and analyzed by experts who have over 4 decades of mushroom growing experience to ensure we provide you with the best extract possible. Unlike other brain supplements for memory and focus, The Real Mushrooms Lion's Mane supplements have measured levels of beta-glucans (most important compound found in mushrooms) verified by 3rd party laboratories.
  • Potent Lions Mane Extract Supplement Good for 60 Days: By choosing Real Mushrooms, you get great value for your money as 1 pouch is already good for 2 months. Featuring 1000 mg of extract in each serving, our lion’s mane contains >30% beta-glucans and undergoes rigorous quality control testing to make them gluten-free, non-GMO, vegan, dairy-free & nut-free.
Special IngredientsVegan, Gluten Free, Organic, Non GMO, Nut Free, Dairy Free, Paleo, Keto, Whole 30
Dosage Form1 gram of lion’s mane mushroom extract powder. No added mycelium, grains or fillers.
Recommended Uses For ProductImmune Support, Brain Health
BrandReal Mushrooms
Diet TypeVegan

The Real Mushrooms Lion’s Mane Mushroom Extract Powder is made using pure, potent & carefully extracted mushroom extracts.

Unlike other mushroom supplements in the market, the Real Mushrooms Lion’s Mane Mushroom Extract Powder is made with actual mushrooms (fruiting bodies). Together with our meticulous hot water extraction process, we’re able to give you a potent & pure mushroom supplement with high levels of bioavailable nutrients in every serving.

The Real Mushrooms Lion’s Mane Mushroom Extract Powder is formulated to provide you with high quality immune support & digestive system boost day in and day out.

High-levels of beta-glucans

Beta−glucans support our immune defenses.

Beta−glucans are the main active beneficial compounds in mushrooms yet very few companies list these on their products, much less measure them.

With Real Mushrooms, all our products have measured levels of beta−glucans to give you a high−quality and effective supplement.

No grains, mycelium or fillers

Supplied to over 1,000 traditional oriental and naturopath practitioners in Canada and the USA.

The fact is, many mushroom products do not actually contain mushrooms. Most are made from the mushroom’s root system called mycelium which is grown on grains like rice, oats, and sorghum.

Contains 100% of mushroom extracts

A carefully hand−picked formula featuring superfood mushrooms popularly used for their immune−boosting properties.

Mushrooms have a tough cell wall made up of chitin which humans have a hard time digesting. This limits us from absorbing the important compounds found in mushrooms.

Extraction is required in order to break down the cell wall and make the beneficial compounds bioavailable to us.

4. Swanson Lion’s Mane Mushroom

Swanson Lion's Mane Mushroom - Herbal Supplement Promoting Mental Focus, Clarity, & Memory Support - Traditional Brain Booster Supplement Made from Hericium Erinaceus - (60 Capsules, 500mg Each)
  • MONEY BACK GUARANTEE: At Swanson, we guarantee that every health product is made from the purest, freshest nutrients. If you aren't satisfied with any product(s) purchased within the last 30 days, return the unused portion to us for a full refund.
  • SUPPORTS MENTAL PERFORMANCE: Our brain support supplement is made from Hericium erinaceus (Mycelium biomass), which aids cognitive health, mood, and mental focus by promoting nerve growth and defending cell integrity within the brain.
  • DOSAGE INSTRUCTIONS: Our wellness supplements offer everyday solutions for an enhanced mind and body. Take one capsule two times per day with water. Consult your physician before using if you are pregnant, nursing, or taking other supplements.
  • OUR QUALITY COMMITMENT: For nearly 50 years, Swanson has delivered science-backed health products worldwide. Each wellness supplement is made in our GMP certified facilities, and our purity and potency testing includes independent third-party labs.
  • TRADITIONAL BRAIN BOOSTER: Lion's mane, or "smart mushroom", has been treasured throughout China and Japan for hundreds of years as both a culinary delicacy and a tonic for enhancing mental alertness while maintaining a feeling of calm.
Dosage FormCapsule
Recommended Uses For ProductBrain Health
BrandSwanson
Age Range (Description)Adult
Unit Count60.00 Count

Swanson Lion’s Mane Mushroom may help promote brain and nerve cell health, plus improve focus, clarity, memory, learning ability and overall cognitive function. Lion’s mane has also been shown to help support a healthy mood and stress response.* Product labels may vary. Same formula. New look.

What is Lion’s Mane Mushroom?

Lion’s mane mushroom (Hericium Erinaceus mycelium biomass) is an edible mushroom native to North America, Europe and Asia. It’s sometimes called lions mane mushroom, bearded tooth fungus, and hedgehog mushroom. Lion’s mane mushroom tends to grow as a single dangling clump or on hardwoods.

Why Consider a Lion’s Mane Mushroom Supplement?

Lion’s mane mushroom supports brain power and mental focus by boosting antioxidant activity in tissues, plus it helps stimulate nerve growth factor (NGF) production for nerve cell health.*

BRAIN & NERVE CELL HEALTH

Swanson’s Lion’s Mane Mushroom herbal supplement supports brain power and nerve cell health by boosting antioxidant activity in the body, helping tissues defend against damage-causing free radicals. Preliminary research has revealed that lion’s mane contains constituents known as erinacines, which may promote brain and nerve cell health.

MENTAL FOCUS & CLARITY

Why do people consider lion’s mane mushroom for mental focus and clarity support? Sometimes called the “smart mushroom,” lion’s mane is revered throughout China and Japan as both a culinary delicacy as well as a tonic for enhancing mental alertness. Swanson Lion’s Mane Mushroom supplement supports focus, clarity, memory, learning ability and overall cognitive function.

500 MG OF LION’S MANE MUSHROOM

Our lion’s mane is from Hericium erinaceus mycelium biomass, an edible mushroom. Each serving (1 capsule) contains 500 mg of lion’s mane mushroom. Swanson Lion’s Mane Mushroom herbal supplement is carefully and rigorously tested to ensure quality, potency and purity.

ALERTNESS & CALM WELLBEING

Lion’s mane mushroom can help promote mental alertness while maintaining a feeling of calm and relaxation, which supports overall mood and a healthy stress response. If you’re looking for mental focus and clarity support without the jitters from caffeine, consider a lion’s mane mushroom herbal supplement. Sometimes lion’s mane mushroom is known as a “brain booster,” enhancing mental alertness and nervous system function.

SCIENCE-BACKED SINCE 1969

Our story began in Fargo, North Dakota, when a man with a passion for golf was looking to lessen his joint pain. His research into the benefits of vitamins and supplements nurtured a deep commitment to wellness at every age and a desire to share his findings with others. In 1969, our first product was vitamin E to support cardiovascular health and antioxidant activity to neutralize free radicals.* Today, we offer thousands of innovative, science-backed wellness solutions that help people live SIMPLY HEALTHIER TOGETHER.

GMP-VERIFIED MANUFACTURER

Swanson products reflect our commitment to quality and service. Every product you purchase is made from the purest, freshest nutrients and meets the highest quality standards. Our facilities are Good Manufacturing Practice (GMP) certified, plus purity and potency testing includes independent third-party labs. Our products are inspired by clinical research backed by scientific consensus. Each is formulated to deliver the highest quality with the lowest environmental impact.

5. New Chapter Lion’s Mane + Reishi Mushroom 

New Chapter Lion's Mane + Reishi Mushroom - LifeShield Mind Force for Mental Clarity with Organic Reishi Mushroom + Vegan + Non-GMO, Nootropic Ingredients - 60 ct
  • 100% Grown in the USA, 100% Vegan, Made with Organic Reishi Mushrooms, Non-GMO Project Verified, Certified Kosher, Gluten Free, Certified Vegan
  • Identity Assured: We use state-of-the-science technologies to match, verify and guarantee each and every mushroom strain
  • Mental Clarity: includes Lion's Mane and organic Reishi Mushroom to provide cognitive support and promote normal brain function.*
  • Science & Tradition: Combines species both revered traditionally and researched extensively for cognitive support*
  • Full Spectrum Mushrooms: Mushrooms are traditionally known to deliver a full spectrum of beneficial compounds, including beta glucans
Dosage FormCapsules,Capsule
BrandNew Chapter
Diet TypeGluten Free, Vegan
Unit Count60 Count
Item Weight0.35 Pounds

Since ancient times, humans have benefited from the unique qualities and compounds of whole, nourishing mushrooms. New Chapter believes it is essential to preserve the whole mushroom and its complete life cycle whenever possible. Some growers only cultivate their strains of mushrooms for a few weeks, never achieving full growth. At New Chapter, we select superior strains and allow them to grow for their full cycle, up to 90 days, to deliver the mushroom’s whole protective shield. The combination of all stages of life—mycelium, fruiting bodies, spores, and extracellular compounds—creates the activated LifeShield™ to support your health and wellness.

The benefits of mushrooms are many and include supporting mental clarity.* LifeShield Mind Force delivers mushrooms’ whole protective shield by combining mycelium, their extracellular compounds, fruiting bodies and spores. It is formulated with select species of tonic mushrooms, including organic Lion’s Mane, to provide cognitive support and promote normal brain function.* LifeShield Mind Force combines species both revered traditionally and researched extensively for cognitive support, such as organic Reishi and organic Chaga.

Additionally, New Chapter uses state-of-the-science technologies to match, verify and guarantee each and every mushroom strain. This includes identification through mushroom DNA testing. *These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Mushrooms for Mental Clarity

Enhance focus and promote normal brain function with nootropic Lion’s Mane and Reishi mushrooms.* Nourish your mental clarity with 100% USA-grown organic mushrooms–great for study or work!

DNA-Tested & ID-Assured

We confirm mushroom identity through DNA testing. We use state-of-the-science technologies to match & verify each and every mushroom strain. The result? With New Chapter mushroom blends, you can be sure you’re getting exactly the mushroom you expect, every time.

Formulated for Absorption

Get the most out of every capsule, formulated with the combined life stages of the mushroom (mycelium, fruiting bodies, spores, and extracellular compounds) that work together to protect your health.

A Reliable Source for Supplements for Lion’s Mane

Because of its potency and purity, supplements from Real Mushrooms are respected by top healthcare professionals and naturopathic physicians in North America. Here is why doctors use and suggest our Lion’s Mane pills, in the words of one of our clients who is a naturopathic physician:

Buying Guide for Lion’s Mane Supplement Take-Away:

Your health may benefit greatly from adding a Lion’s Mane supplement to your everyday routine. And fortunately for you, finding high-quality supplements made from medicinal mushrooms has never been simpler.

However, since functional mushroom supplements have gained popularity, there are a lot of lower-quality items available on the market.

To ensure you are purchasing a secure, highly pure, and highly effective mushroom supplement, keep in mind the following advice:

Try to determine the product’s actual composition by reading the Supplement Facts panel.

Choose goods that mostly include the fruiting body of the mushroom, not only the mycelium.

Avoid purchasing items that are missing details regarding the plant component of the fungal.

Seek out companies whose Supplement Facts panel includes a list of the beta-glucans they contain. It must appear in the Supplement Facts panel and not only in promotional materials.

Verify that the ingredients were farmed organically.

Always go with a reputable source that is transparent about the testing procedures they follow and the extract processes they utilize.

Try the Real Mushrooms Lion’s Mane powder or capsules if you want a Lion’s Mane product that is respected by both customers and health professionals.

FAQs

Does lion’s mane supplement work?

Research has found that lion’s mane may protect against dementia, reduce mild symptoms of anxiety and depression and help repair nerve damage. It also has strong anti-inflammatory, antioxidant and immune-boosting abilities and has been shown to lower the risk of heart disease, cancer, ulcers, and diabetes in animals.

Should I take lion’s mane everyday?

Lion’s mane can be taken up to three times per day, though it is not recommended to exceed this limit. Daily dosages of 250mg to 750mg have also been shown to be effective. We recommend mixing one scoop of lion’s mane powdered mix into your tea or coffee, once a day for a two week period.

Are there negative effects of lion’s mane?

Bleeding conditions: Lion’s mane mushroom might slow blood clotting. This might increase the chances of bruising and bleeding in people with bleeding conditions. Surgery: Lion’s mane mushroom might slow blood clotting and reduce blood glucose levels.

Conclusion

While Lion’s Mane is not expected to cause any major side effects, there is a small possibility of experiencing stomach discomfort or allergic reactions in response to the use of this mushroom. People who have a sensitivity to mushrooms may also experience some irritation when using this product. Women who are pregnant or breastfeeding are advised to avoid this supplement and other medicinal mushrooms, as they contain substances that might interfere with the development and growth of an unborn child. As with anything you ingest, always start with a low dosage (2-3 times per week) and see how your body responds before increasing frequency or quantity.

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